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KMID : 0386520160250010119
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Research Institute of Korean Medicone
2016 Volume.25 No. 1 p.119 ~ p.132
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The anti-atopic effect of natural carbonated hot spring water on DNCB-induced NC/Nga mice under different temperature
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Go Ga-Yeon
Park Jung-Hwan
Jang Soon-Woo
Kim Yoon-Ha
Park Jung-Mi
Ahn Taek-Won
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Abstract
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Objectives : The aim of this study is to investigate the effect of natural carbonated hot spring water (NCHW) on DNCB-induced NC/Nga mice, an atopic dermatitis (AD) model.
Methods :At first, NC/Nga mice were prepared and induced to have atopic lesion on their back skin by dinitrochlorobenzene (DNCB). They swam for 20 minutes everyday in tanks where the one is filled with 28℃ NCHW, the other is with 25℃ carbonated hot spring water and another is with artificial carbonated hot spring water (ACHW). After 3 weeks, We assessed the skin clinical score and macroscopic appearance, total IgE, IgG1 levels, WBC differential counting, IFN-?, IL-4, IL-13, TNF-α production levels and histological changes.
Results : There are meaningful results of improving atopic lesion-state by relieving the count of total IgE, IgG1 levels, WBC differential counting, IFN-?, IL-4, IL-13, TNF-α production levels and recovering skin clinical score in the group with 28℃ NCHW in comparison with the other groups.
Conclusions : The NCHW may have potential as an effective treatment for atopic dermatitis.
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KEYWORD
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Natural carbonated hot spring water , Atopic dermatitis
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